Abortion
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It matters because the abortion debate is largely about what rights (if any) an unborn baby has. Personhood determines those rights. Killing a person is morally (and legally) different from killing a non-person, so you need to know when personhood starts.
It’s true that you know personhood will start at some point as long as you don’t interfere, but this is for people who do want to interfere without committing a moral (or legal) crime.