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Conversely, non-inferential novelty does not follow by any inference or deduction; it is not implicit in existing knowledge, so it is not in any set of knowledge's implication space (except that of the laws of physics...).

Knowledge which is novel in this way is what constitutes creation in the sense we mean in epistemology. The two known examples of non-inferential knowledge growth are biological evolution and some of the thinking which takes place in the minds of people (human or AGI).

Any given set of knowledge cannot grow itself non-inferentially. There must be a source of novelty, of variation, that is epistemically external to it.
If we take that claim as general, then the mutation of DNA constituting the creation/novelty/knowledge-growth in biology is a specific instance: cosmic ray strikes and errors in copying due to chemistry are sources of variation not caused by the DNA’s knowledge).