Fabric of Reality Book Club

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Erik Orrje’s avatar
Erik Orrje, 2 months ago·#2031

How do you think of "problems" for genes?

Dirk Meulenbelt’s avatar
Dirk Meulenbelt, 2 months ago·#2149

I don't think a gene has problems. It does not have ideas.

Criticized1*
Dennis Hackethal’s avatar
Dennis Hackethal, 2 months ago·#2151

A gene doesn’t have problems in any conscious sense, but it always faces the problem of how to spread through the population at the expense of its rivals.

Maybe that answers your question, Erik.

Criticism of #2149
Dirk Meulenbelt’s avatar
Dirk Meulenbelt, 2 months ago·#2152

How could we integrate that vision with Popper's definition (paraphrased): a tension, inconsistency, or unmet explanatory demand that arises when a theory clashes with observations, background assumptions, or rival theories, thereby calling for conjectural solutions and critical tests.

Dennis Hackethal’s avatar
Dennis Hackethal, 2 months ago·#2153

The rival theories and clashes sound like competition between genes – or more precisely, between the theories those genes embody.

Basically, genes contain guesses (in a non-subjective sense) for how to spread through the population at the expense of their rivals. Those guesses are met with selection pressure and competition.

Dirk Meulenbelt’s avatar
Dirk Meulenbelt, 2 months ago·#2154

Dirk approves of your comment.

Erik Orrje’s avatar
Erik Orrje, 2 months ago·#2190

Yeah, thanks! Are ideas also guesses of how to survive in the mind and across substrates, or is there more to ideas?

Dennis Hackethal’s avatar
Dennis Hackethal, 2 months ago·#2200

In the neo-Darwinian view, any replicator’s primary ‘concern’ is how to spread through the population at the expense of its rivals. This view is what Dawkins (IIRC) calls the gene’s eye view, and it applies to ideas as much as it does to genes. Any adaptation of any replicator is primarily in service of this concern.

So I think the answer to your question, “Are ideas also guesses of how to survive in the mind and across substrates …?”, is ‘yes’.

Battle tested
Erik Orrje’s avatar
Erik Orrje revised about 2 months ago·#2329
4th of 4 versions

Most people (except in Alzheimer's, etc.) don't run out of memory in the brain. The reason most people don’t (permanently) run out memory (of either kind) isn’t that memory isn’t scarce, but that there’s a pruning mechanism in the mind. And there’s competition.

Dennis Hackethal’s avatar
Dennis Hackethal, 2 months ago·#2230

Since you’re a doctor, Erik, let me ask: is there a possibility Alzheimer’s could be explained in terms of bad software? Correct me if I’m wrong, but it seems like the prevailing view is limited to bad hardware.

Criticized1
Erik Orrje’s avatar
Erik Orrje revised 2 months ago·#2272
2nd of 2 versions

Hmm never thought of that, interesting! I think since the disease involves continuous loss of brain volume, hardware decay seems like the best explanation.

In general I think it makes sense to speak of diseases in neurology (e.g. Alzheimer's, Parkinsons, stroke) as bad hardware and psychiatric disease as bad software. But it could very well be that some of those diagnoses are miscategorised.

Criticism of #2230
Dirk Meulenbelt’s avatar
Dirk Meulenbelt, 2 months ago·#2241

Not a doctor. But it's not hard for me to imagine untainted memory but a script with an error such that it can't manage to look up the information.

Criticized1
Erik Orrje’s avatar
Erik Orrje revised 2 months ago·#2270
2nd of 2 versions

Yeah that's definitely a possible medical condition, e.g. in psychosis or after having ECT. Don't think it's the best explanation for Alzheimer's though, where the loss of brain volume is so apparent.

Criticism of #2241
Dennis Hackethal’s avatar
Dennis Hackethal, about 2 months ago·#2334

In your revision, you asked me to let you know if you are doing things incorrectly.

You can revise ideas the way you did, it’s not wrong per se, but revisions are better for incremental changes. They’re not really meant for taking back criticisms or indicating agreement. If a criticism of yours is successfully counter-criticized and you would like to abandon it, I would just leave it counter-criticized and not revise it further.

If you are looking for a way to indicate agreement (with a counter-criticism, say), it’s something Dirk and I have been discussing offline, see #2169. I hope to implement something to that effect soon.

Dennis Hackethal’s avatar
Dennis Hackethal, about 2 months ago·#2335

#2325 serves as an example. I had submitted a criticism which is now outdated and remains counter-criticized. It’s actually better that way because it shows that an error has been corrected, and makes it less likely for others to submit a duplicate criticism.

Benjamin Davies’s avatar
Benjamin Davies, 14 days ago·#3278

… any replicator’s primary ‘concern’ is how to spread through the population at the expense of its rivals.

Why “through the population”? Doesn’t this presuppose a replicator needs to exist within a population to do what it does? The first replicator spread with no population to spread into.

Criticism of #2200Criticized3
Dennis Hackethal’s avatar
Dennis Hackethal, 14 days ago·#3295

I suppose it’s theoretically possible for the very first replicator to exist in isolation until it replicates for the first time. But that’s what it does right away anyway.

Criticism of #3278
Dennis Hackethal’s avatar
Dennis Hackethal, 14 days ago·#3296

Accounts of the origin of replicators (such as RNA World) involve proto-replicators. By the time the first ‘full-fledged’ replicator came on the scene, it was already part of a larger population of proto-replicators.

Criticism of #3278
Dennis Hackethal’s avatar
Dennis Hackethal, 14 days ago·#3297

A population of 1 is still a population.

Criticism of #3278
Benjamin Davies’s avatar
Benjamin Davies, 14 days ago·#3279

… any replicator’s primary ‘concern’ is how to spread through the population at the expense of its rivals.

Why “at the expense of its rivals”? Isn’t the concern to spread at all, regardless of the outcome of rivals?

Criticism of #2200Criticized2
Dennis Hackethal’s avatar
Dennis Hackethal, 14 days ago·#3293

Rivalry means competition, win/lose outcomes. If one replicator spreads, it will be at the expense of its rivals (if any), eg taking up niches that rivals would otherwise have taken up.

Criticism of #3279
Dennis Hackethal’s avatar
Dennis Hackethal, 14 days ago·#3294

I’m using standard neo-Darwinian phrasing. Compare, for example, BoI chapter 4:

The most general way of stating the central assertion of the neo-Darwinian theory of evolution is that a population of replicators subject to variation (for instance by imperfect copying) will be taken over by those variants that are better than their rivals at causing themselves to be replicated.

And, same chapter:

[T]he knowledge embodied in genes is knowledge of how to get themselves replicated at the expense of their rivals.

See also several instances in chapter 15 in the context of meme evolution.

Richard Dawkins’ The Selfish Gene has a ton on rivals (alleles), too, for example (chapter 2):

Ways of increasing stability and of decreasing rivals’ stability became more elaborate and more efficient. Some of them may even have ‘discovered’ how to break up molecules of rival varieties chemically, and to use the building blocks so released for making their own copies.

Criticism of #3279